Vaccines Europe pipeline review

Dashboard

Vaccines Europe conducted a pipeline review of its 16 member companies, including information up to August 2025.

The review shows a promising immunisation pipeline aimed at addressing new and emerging health threats, such as the burden of respiratory-transmitted infections, antimicrobial resistance, challenges brought about by the ageing of the population, climate change and zoonotic infections, through leveraging a broad array of immunisation technologies.

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Overview data

91

candidates in Vaccines Europe membersโ€™ pipeline, comprising 86 prophylactic and 2 therapeutic vaccines, and 3 prophylactic monoclonal antibodies

41%

of candidates aim to address disease areas for which no vaccine or prophylactic mAb has been registered yet

59%

of candidates aim to further develop existing products or find a new approach to address a disease

46

candidates are for routine immunisation

4

candidates against infection-associated cancers

17

candidates targeting bacteria associated with significant antibiotic resistance

Over 80%

of candidates are tested in adults and/or older adults

12

immunisation technologies being used by Vaccines Europe members

68

candidates target respiratory-transmitted infections

6

travel vaccine candidates are in the pipeline

31

candidates target zoonotic diseases

6

candidates target sexually-transmitted infections (STIs)

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all_diseases_area
All Disease Areas
technology_platform
Immunisation technology
development_phases
Development Phases
trial_population
Trial Population

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acne Acne
chlamydia Chlamydia
clostridioides ๐˜Š๐˜ญ๐˜ฐ๐˜ด๐˜ต๐˜ณ๐˜ช๐˜ฅ๐˜ช๐˜ฐ๐˜ช๐˜ฅ๐˜ฆ๐˜ด ๐˜ฅ๐˜ช๐˜ง๐˜ง๐˜ช๐˜ค๐˜ช๐˜ญ๐˜ฆ infection (CDI)
covid-19 Coronaviruses
cytomegalovirus Cytomegalovirus (CMV)
dengue-fever Dengue fever
epstein-barr-virus Epstein-Barr virus (EBV) infection
streptococcus Group B ๐˜š๐˜ต๐˜ณ๐˜ฆ๐˜ฑ๐˜ต๐˜ฐ๐˜ค๐˜ฐ๐˜ค๐˜ค๐˜ถ๐˜ด Infection
herpes-simplex Herpes simplex virus
hiv Human immunodeficiency virus (HIV)
hpv Human papillomavirus (HPV)
influenza Influenza (Seasonal)
influenza pandemic Influenza (Pandemic)
lyme-disease-image Lyme disease (Borreliosis)
measles Measles, mumps, rubella, varicella
meningococcal-disease Meningococcal disease
mpox Mpox
nipah-virus Nipah virus (NiV)
norovirus Norovirus
pneumococcal-disease Pneumococcal disease
pseudomonas ๐˜—๐˜ด๐˜ฆ๐˜ถ๐˜ฅ๐˜ฐ๐˜ฎ๐˜ฐ๐˜ฏ๐˜ข๐˜ด ๐˜ข๐˜ฆ๐˜ณ๐˜ถ๐˜จ๐˜ช๐˜ฏ๐˜ฐ๐˜ด๐˜ข infection
rabies Rabies
rsv Respiratory syncytial virus (RSV)
salmonella ๐˜š๐˜ข๐˜ญ๐˜ฎ๐˜ฐ๐˜ฏ๐˜ฆ๐˜ญ๐˜ญ๐˜ข
shigellosis Shigellosis
staphylococcus ๐˜š๐˜ต๐˜ข๐˜ฑ๐˜ฉ๐˜บ๐˜ญ๐˜ฐ๐˜ค๐˜ฐ๐˜ค๐˜ค๐˜ถ๐˜ด ๐˜ข๐˜ถ๐˜ณ๐˜ฆ๐˜ถ๐˜ด infection
e.coli Uropathogenic ๐˜Œ.๐˜ค๐˜ฐ๐˜ญ๐˜ช (UPEC)
varicella Varicella-Zoster Virus (VZV), varicella/shingles
yellow-fever-e1689505535523-1 Yellow fever
zika-image Zika

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Generalised Modules for Membrane Antigens
๐˜š๐˜ข๐˜ญ๐˜ฎ๐˜ฐ๐˜ฏ๐˜ฆ๐˜ญ๐˜ญ๐˜ข
Glycoconjugate vaccine
Group B ๐˜š๐˜ต๐˜ณ๐˜ฆ๐˜ฑ๐˜ต๐˜ฐ๐˜ค๐˜ฐ๐˜ค๐˜ค๐˜ถ๐˜ด Infection Pneumococcal disease Shigellosis
Live-attenuated virus
Dengue fever Measles, mumps, rubella, varicella Respiratory syncytial virus (RSV) Varicella-Zoster Virus (VZV), varicella/shingles Yellow fever
Monoclonal antibody
๐˜Š๐˜ญ๐˜ฐ๐˜ด๐˜ต๐˜ณ๐˜ช๐˜ฅ๐˜ช๐˜ฐ๐˜ช๐˜ฅ๐˜ฆ๐˜ด ๐˜ฅ๐˜ช๐˜ง๐˜ง๐˜ช๐˜ค๐˜ช๐˜ญ๐˜ฆ infection (CDI) ๐˜—๐˜ด๐˜ฆ๐˜ถ๐˜ฅ๐˜ฐ๐˜ฎ๐˜ฐ๐˜ฏ๐˜ข๐˜ด ๐˜ข๐˜ฆ๐˜ณ๐˜ถ๐˜จ๐˜ช๐˜ฏ๐˜ฐ๐˜ด๐˜ข infection ๐˜š๐˜ต๐˜ข๐˜ฑ๐˜ฉ๐˜บ๐˜ญ๐˜ฐ๐˜ค๐˜ฐ๐˜ค๐˜ค๐˜ถ๐˜ด ๐˜ข๐˜ถ๐˜ณ๐˜ฆ๐˜ถ๐˜ด infection
Multiple Antigen Presenting System (MAPS)
Pneumococcal disease
Multiple platforms
Meningococcal disease ๐˜š๐˜ข๐˜ญ๐˜ฎ๐˜ฐ๐˜ฏ๐˜ฆ๐˜ญ๐˜ญ๐˜ข
Protein nanoparticles
Coronaviruses Epstein-Barr virus (EBV) infection Influenza (Seasonal)
Protein subunit
Coronaviruses Cytomegalovirus (CMV) Influenza (Seasonal) Influenza (Pandemic) Lyme disease (Borreliosis) Respiratory syncytial virus (RSV) Uropathogenic ๐˜Œ.๐˜ค๐˜ฐ๐˜ญ๐˜ช (UPEC)
RNA
Acne Chlamydia Coronaviruses Cytomegalovirus (CMV) Epstein-Barr virus (EBV) infection Herpes simplex virus Human immunodeficiency virus (HIV) Influenza (Seasonal) Influenza (Pandemic) Lyme disease (Borreliosis) Mpox Nipah virus (NiV) Norovirus Respiratory syncytial virus (RSV) Varicella-Zoster Virus (VZV), varicella/shingles Zika
Toxoid vaccine
๐˜Š๐˜ญ๐˜ฐ๐˜ด๐˜ต๐˜ณ๐˜ช๐˜ฅ๐˜ช๐˜ฐ๐˜ช๐˜ฅ๐˜ฆ๐˜ด ๐˜ฅ๐˜ช๐˜ง๐˜ง๐˜ช๐˜ค๐˜ช๐˜ญ๐˜ฆ infection (CDI)
Virus-like particle
Human papillomavirus (HPV)
Whole-inactivated virus
Influenza (Seasonal) Influenza (Pandemic) Rabies Zika

CHOOSE A DEVELOPMENT PHASE

phase-I

Phase I

Chlamydia ๐˜Š๐˜ญ๐˜ฐ๐˜ด๐˜ต๐˜ณ๐˜ช๐˜ฅ๐˜ช๐˜ฐ๐˜ช๐˜ฅ๐˜ฆ๐˜ด ๐˜ฅ๐˜ช๐˜ง๐˜ง๐˜ช๐˜ค๐˜ช๐˜ญ๐˜ฆ infection (CDI) Coronaviruses Epstein-Barr virus (EBV) infection Human immunodeficiency virus (HIV) Human papillomavirus (HPV) Influenza (Seasonal) Influenza (Pandemic) Nipah virus (NiV) Pneumococcal disease Respiratory syncytial virus (RSV) Varicella-Zoster Virus (VZV), varicella/shingles Zika
phase-II

Phase II

Acne ๐˜Š๐˜ญ๐˜ฐ๐˜ด๐˜ต๐˜ณ๐˜ช๐˜ฅ๐˜ช๐˜ฐ๐˜ช๐˜ฅ๐˜ฆ๐˜ด ๐˜ฅ๐˜ช๐˜ง๐˜ง๐˜ช๐˜ค๐˜ช๐˜ญ๐˜ฆ infection (CDI) Coronaviruses Cytomegalovirus (CMV) Epstein-Barr virus (EBV) infection Herpes simplex virus Influenza (Seasonal) Influenza (Pandemic) Lyme disease (Borreliosis) Measles, mumps, rubella, varicella Meningococcal disease Mpox Norovirus Pneumococcal disease ๐˜—๐˜ด๐˜ฆ๐˜ถ๐˜ฅ๐˜ฐ๐˜ฎ๐˜ฐ๐˜ฏ๐˜ข๐˜ด ๐˜ข๐˜ฆ๐˜ณ๐˜ถ๐˜จ๐˜ช๐˜ฏ๐˜ฐ๐˜ด๐˜ข infection Respiratory syncytial virus (RSV) ๐˜š๐˜ข๐˜ญ๐˜ฎ๐˜ฐ๐˜ฏ๐˜ฆ๐˜ญ๐˜ญ๐˜ข Shigellosis ๐˜š๐˜ต๐˜ข๐˜ฑ๐˜ฉ๐˜บ๐˜ญ๐˜ฐ๐˜ค๐˜ฐ๐˜ค๐˜ค๐˜ถ๐˜ด ๐˜ข๐˜ถ๐˜ณ๐˜ฆ๐˜ถ๐˜ด infection Uropathogenic ๐˜Œ.๐˜ค๐˜ฐ๐˜ญ๐˜ช (UPEC) Varicella-Zoster Virus (VZV), varicella/shingles Zika
phase-III

Phase III

Coronaviruses Cytomegalovirus (CMV) Dengue fever Group B ๐˜š๐˜ต๐˜ณ๐˜ฆ๐˜ฑ๐˜ต๐˜ฐ๐˜ค๐˜ฐ๐˜ค๐˜ค๐˜ถ๐˜ด Infection Influenza (Seasonal) Lyme disease (Borreliosis) Norovirus Pneumococcal disease Rabies Respiratory syncytial virus (RSV) Varicella-Zoster Virus (VZV), varicella/shingles Yellow fever
under-review

Under Regulatory Review

Coronaviruses Influenza (Seasonal) Respiratory syncytial virus (RSV)

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paediatric

Paediatric

Coronaviruses Dengue fever Epstein-Barr virus (EBV) infection Lyme disease (Borreliosis) Measles, mumps, rubella, varicella Meningococcal disease Pneumococcal disease ๐˜—๐˜ด๐˜ฆ๐˜ถ๐˜ฅ๐˜ฐ๐˜ฎ๐˜ฐ๐˜ฏ๐˜ข๐˜ด ๐˜ข๐˜ฆ๐˜ณ๐˜ถ๐˜จ๐˜ช๐˜ฏ๐˜ฐ๐˜ด๐˜ข infection Rabies Respiratory syncytial virus (RSV) ๐˜š๐˜ข๐˜ญ๐˜ฎ๐˜ฐ๐˜ฏ๐˜ฆ๐˜ญ๐˜ญ๐˜ข Shigellosis Varicella-Zoster Virus (VZV), varicella/shingles
adults

Adults

Acne Chlamydia ๐˜Š๐˜ญ๐˜ฐ๐˜ด๐˜ต๐˜ณ๐˜ช๐˜ฅ๐˜ช๐˜ฐ๐˜ช๐˜ฅ๐˜ฆ๐˜ด ๐˜ฅ๐˜ช๐˜ง๐˜ง๐˜ช๐˜ค๐˜ช๐˜ญ๐˜ฆ infection (CDI) Coronaviruses Cytomegalovirus (CMV) Dengue fever Epstein-Barr virus (EBV) infection Group B ๐˜š๐˜ต๐˜ณ๐˜ฆ๐˜ฑ๐˜ต๐˜ฐ๐˜ค๐˜ฐ๐˜ค๐˜ค๐˜ถ๐˜ด Infection Herpes simplex virus Human immunodeficiency virus (HIV) Human papillomavirus (HPV) Influenza (Seasonal) Influenza (Pandemic) Lyme disease (Borreliosis) Meningococcal disease Mpox Nipah virus (NiV) Norovirus Pneumococcal disease ๐˜—๐˜ด๐˜ฆ๐˜ถ๐˜ฅ๐˜ฐ๐˜ฎ๐˜ฐ๐˜ฏ๐˜ข๐˜ด ๐˜ข๐˜ฆ๐˜ณ๐˜ถ๐˜จ๐˜ช๐˜ฏ๐˜ฐ๐˜ด๐˜ข infection Rabies Respiratory syncytial virus (RSV) ๐˜š๐˜ข๐˜ญ๐˜ฎ๐˜ฐ๐˜ฏ๐˜ฆ๐˜ญ๐˜ญ๐˜ข ๐˜š๐˜ต๐˜ข๐˜ฑ๐˜ฉ๐˜บ๐˜ญ๐˜ฐ๐˜ค๐˜ฐ๐˜ค๐˜ค๐˜ถ๐˜ด ๐˜ข๐˜ถ๐˜ณ๐˜ฆ๐˜ถ๐˜ด infection Uropathogenic ๐˜Œ.๐˜ค๐˜ฐ๐˜ญ๐˜ช (UPEC) Varicella-Zoster Virus (VZV), varicella/shingles Yellow fever Zika
older-adults

Older Adults

Acne Coronaviruses Influenza (Seasonal) Influenza (Pandemic) Norovirus Pneumococcal disease ๐˜—๐˜ด๐˜ฆ๐˜ถ๐˜ฅ๐˜ฐ๐˜ฎ๐˜ฐ๐˜ฏ๐˜ข๐˜ด ๐˜ข๐˜ฆ๐˜ณ๐˜ถ๐˜จ๐˜ช๐˜ฏ๐˜ฐ๐˜ด๐˜ข infection Rabies Respiratory syncytial virus (RSV) Varicella-Zoster Virus (VZV), varicella/shingles

N/A

Pneumococcal disease

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ico-antimicrobal
Antimicrobal resistance

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clostridioides ๐˜Š๐˜ญ๐˜ฐ๐˜ด๐˜ต๐˜ณ๐˜ช๐˜ฅ๐˜ช๐˜ฐ๐˜ช๐˜ฅ๐˜ฆ๐˜ด ๐˜ฅ๐˜ช๐˜ง๐˜ง๐˜ช๐˜ค๐˜ช๐˜ญ๐˜ฆ infection (CDI)
streptococcus Group B ๐˜š๐˜ต๐˜ณ๐˜ฆ๐˜ฑ๐˜ต๐˜ฐ๐˜ค๐˜ฐ๐˜ค๐˜ค๐˜ถ๐˜ด Infection
pneumococcal-disease Pneumococcal disease
pseudomonas ๐˜—๐˜ด๐˜ฆ๐˜ถ๐˜ฅ๐˜ฐ๐˜ฎ๐˜ฐ๐˜ฏ๐˜ข๐˜ด ๐˜ข๐˜ฆ๐˜ณ๐˜ถ๐˜จ๐˜ช๐˜ฏ๐˜ฐ๐˜ด๐˜ข infection
salmonella ๐˜š๐˜ข๐˜ญ๐˜ฎ๐˜ฐ๐˜ฏ๐˜ฆ๐˜ญ๐˜ญ๐˜ข
shigellosis Shigellosis
staphylococcus ๐˜š๐˜ต๐˜ข๐˜ฑ๐˜ฉ๐˜บ๐˜ญ๐˜ฐ๐˜ค๐˜ฐ๐˜ค๐˜ค๐˜ถ๐˜ด ๐˜ข๐˜ถ๐˜ณ๐˜ฆ๐˜ถ๐˜ด infection
e.coli Uropathogenic ๐˜Œ.๐˜ค๐˜ฐ๐˜ญ๐˜ช (UPEC)
ico-climate-change
Climate change

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dengue-fever Dengue fever
salmonella ๐˜š๐˜ข๐˜ญ๐˜ฎ๐˜ฐ๐˜ฏ๐˜ฆ๐˜ญ๐˜ญ๐˜ข
shigellosis Shigellosis
yellow-fever-e1689505535523-1 Yellow fever
zika-image Zika
ico-infection-associated 60×60
Infection-associated cancer vaccines

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epstein-barr-virus Epstein-Barr virus (EBV) infection
hpv Human papillomavirus (HPV)
maternal immunisation
Maternal immunisation

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streptococcus Group B ๐˜š๐˜ต๐˜ณ๐˜ฆ๐˜ฑ๐˜ต๐˜ฐ๐˜ค๐˜ฐ๐˜ค๐˜ค๐˜ถ๐˜ด Infection
respiratory infections
Respiratory infections

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covid-19 Coronaviruses
influenza Influenza (Seasonal)
influenza pandemic Influenza (Pandemic)
measles Measles, mumps, rubella, varicella
meningococcal-disease Meningococcal disease
mpox Mpox
pneumococcal-disease Pneumococcal disease
rsv Respiratory syncytial virus (RSV)
varicella Varicella-Zoster Virus (VZV), varicella/shingles
ico-routine-vaccine
Routine vaccines across the lifespan

CHOOSE THE DISEASE OR PATHOGEN

hpv Human papillomavirus (HPV)
influenza Influenza (Seasonal)
measles Measles, mumps, rubella, varicella
meningococcal-disease Meningococcal disease
pneumococcal-disease Pneumococcal disease
rsv Respiratory syncytial virus (RSV)
varicella Varicella-Zoster Virus (VZV), varicella/shingles
sexually transmitted infections
Sexually-transmitted infections

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chlamydia Chlamydia
herpes-simplex Herpes simplex virus
hiv Human immunodeficiency virus (HIV)
hpv Human papillomavirus (HPV)
mpox Mpox
ico-therapeutic
Therapeutic infectious disease vaccines

CHOOSE THE DISEASE OR PATHOGEN

acne Acne
herpes-simplex Herpes simplex virus
ico-travel-vaccines-1
Travel vaccines

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dengue-fever Dengue fever
meningococcal-disease Meningococcal disease
rabies Rabies
salmonella ๐˜š๐˜ข๐˜ญ๐˜ฎ๐˜ฐ๐˜ฏ๐˜ฆ๐˜ญ๐˜ญ๐˜ข
yellow-fever-e1689505535523-1 Yellow fever
ico-pandemic
Zoonoses and pandemic preparedness

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covid-19 Coronaviruses
dengue-fever Dengue fever
influenza pandemic Influenza (Pandemic)
lyme-disease-image Lyme disease (Borreliosis)
mpox Mpox
nipah-virus Nipah virus (NiV)
rabies Rabies
salmonella ๐˜š๐˜ข๐˜ญ๐˜ฎ๐˜ฐ๐˜ฏ๐˜ฆ๐˜ญ๐˜ญ๐˜ข
yellow-fever-e1689505535523-1 Yellow fever

Charts

By the end of August 2025, there were 91 candidates in the Vaccines Europe membersโ€™ pipeline. Most of these target infectious diseases caused by viruses. The majority of vaccine candidates are developed in the adult population. Meanwhile, almost half of the vaccine candidates target diseases for which there are no registered vaccines yet.

How can Europe take full advantage of this promising vaccines pipeline?

1
Ensure sustainable immunisation financing in EU Member States
2
Enhance vaccine market access pathways in Europe
3
Embed adult vaccination in national immunisation programmes to improve country readiness

EU Vaccines Pipeline Review

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Pipeline review 2024
Pipeline review 2023
Pipeline review 2022