Influenza (Seasonal)

General Information

Influenza virus types A and B are both common causes of acute respiratory illnesses.

Severe morbidity and mortality more common among elderly people and in specific high-risk groups.

Influenza viruses undergo frequent changes in their surface antigens, with new influenza outbreaks occurring every year.

Transmission

Influenza viruses spread from person to person, primarily through respiratory droplets.

Symptoms

General symptoms are generally localised to the respiratory tract and include nonproductive cough, fever, headache, malaise, muscle aches, rhinitis and sore throat.

Illness without fever can occur, especially in older adults and infants.

Complications of influenza virus infection include primary influenza viral pneumonia and secondary bacterial pneumonia, as well as ear and sinus infections and worsening of chronic medical conditions (congestive heart failure, asthma, diabetes).

Epidemiology

There are around 1 billion cases of seasonal influenza annually, causing 290,000 to 650,000 respiratory deaths every year.

Influenza (seasonal)

Vaccines Pipeline

20
Vaccines in
the pipeline

IMMUNISATION TECHNOLOGY

Protein nanoparticles (2)
Protein subunit (4)
mRNA (13)
Whole-inactivated virus (1)

DEVELOPMENT PHASES

Phase I (6)
Phase II (7)
Phase III (6)
Regulatory review (1)

TRIAL POPULATION

Adults (5)
Adults + Older Adults (11)
Older Adults (4)

Source:
WHO. Influenza (seasonal). 2023. Available from: https://www.who.int/news-room/fact-sheets/detail/influenza-(seasonal).
[Accessed: August 2025]