Yellow fever

General Information

Yellow fever is an acute viral haemorrhagic disease endemic in tropical areas of Africa and Central and South America.

Yellow fever is prevented by an extremely effective vaccine, which is safe and affordable. A single dose of yellow fever vaccine is sufficient to grant sustained immunity and life-long protection against yellow fever disease.

Transmission

Yellow fever is transmitted by infected mosquitoes.

Symptoms

Symptoms of yellow fever include hemorrhagic fever, headache, jaundice, muscle pain, nausea, vomiting and fatigue.

A small proportion of patients who contract the virus develop severe symptoms and approximately half of those die within 7 to 10 days.

Epidemiology

20% to 50% of infected persons who develop severe disease die.

Yellow fever virus is estimated to cause 200,000 cases of disease and 30,000 deaths each year, with 90% occurring in Africa.

Vaccines Pipeline

1
Vaccines in
the pipeline

TECHNOLOGY PLATFORMS

Live-attenuated virus​ (1)

DEVELOPMENT PHASES

Phase II (1)

TRIAL POPULATION

Paediatric + Adults + Older Adults (1)

Sources:
WHO. Yellow fever. 2023 [cited 2023 August]. Available from: https://www.who.int/news-room/fact-sheets/detail/yellow-fever.
CDC. Yellow fever. 2018 [cited 2023 August]. Available from: https://www.cdc.gov/globalhealth/newsroom/topics/yellowfever/index.html.