Measles, Mumps, Rubella, Varicella

General Information

Measles: highly contagious viral disease that can lead to severe complications and death. Vaccination averted 57 million deaths between 2000 and 2022.

Mumps: contagious viral disease characterised by swelling of the salivary glands.

Rubella: leading vaccine-preventable cause of birth defects, accounting for an estimated 100,000 infants born with congenital rubella syndrome (CRS) each year worldwide.

Transmission

Measles: it spreads easily when an infected person breathes, coughs or sneezes.

Mumps: it is transmitted by aerosol and respiratory droplets.

Rubella: it is transmitted by airborne droplets when infected people sneeze or cough.

Symptoms

Measles: A prominent rash is the most visible symptom. Early symptoms usually last 4–7 days and include running nose, cough, red and watery eyes and small white spots inside the cheeks.

Mumps: The most common clinical presentation of mumps is an acute and tender parotid swelling which develops 16–18 days after exposure in up to 70% of cases. Parotitis may be preceded by non-specific symptoms lasting 3–5 days including malaise, fever, headache, myalgia and arthralgia.

Rubella: the infection usually causes a mild fever and rash in children and adults; during pregnancy, the infection can result in miscarriage, fetal death, stillbirth, or infants with congenital malformations, known as congenital rubella syndrome (CRS).

Epidemiology

Measles: In 2022, approximately 136,000 deaths were caused by measles globally, mostly in children under the age of 5.

Mumps: In 2022, 2,593 mumps cases were reported in the EU/EEA.

Rubella: In 2022, there were an estimated 17,865 cases of rubella in 78 countries.

Vaccines Pipeline

1
Vaccines in
the pipeline

TECHNOLOGY PLATFORMS

Live-attenuated virus (1)

DEVELOPMENT PHASES

Phase II (1)

TRIAL POPULATION

Paediatric (1)

Sources:
WHO. Measles. 2024. Available from: https://www.who.int/news-room/fact-sheets/detail/measles.
ECDC. Mumps. Available from: https://www.ecdc.europa.eu/en/mumps.
ECDC. Mumps – Annual Epidemiological Report for 2022. 2024. Available from: https://www.ecdc.europa.eu/en/publications-data/mumps-annual-epidemiological-report-2022.
WHO. Rubella. 2024. Available from: https://www.who.int/news-room/fact-sheets/detail/rubella.
[Accessed: August 2024]