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Zika

General Information

Zika virus disease is caused by a virus transmitted primarily by infected mosquitoes.

Symptoms are generally mild and include fever, rash, conjunctivitis, muscle and joint pain, malaise or headache. Symptoms typically last for 2–7 days. Most people with Zika virus infection do not develop symptoms.

Zika virus infection during pregnancy can cause infants to be born with microcephaly and other congenital malformations, known as congenital Zika syndrome. Infection with Zika virus is also associated with other complications of pregnancy including preterm birth and miscarriage.

An increased risk of neurologic complications is associated with Zika virus infection in adults and children, including Guillain-Barré syndrome, neuropathy and myelitis.

There are currently no licensed vaccines or treatments for Zika.

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Epidemiology

2016

From May 15, 2015, when the Zika virus was confirmed in Brazil, to Dec. 15, 2016, 707,133 Zika virus cases were reported in the Americas.

Vaccines
Pipeline

3
Vaccines in
the pipeline

Technology Platforms

  • mRNA (1)
  • Whole-inactivated virus (2)

DEVELOPMENT PHASES

  • Phase I (2)
  • Phase II (1)

TRIAL POPULATION

    Paediatric + Adults (1)​
    Adults (2)​

Sources: 
https://www.who.int/news-room/fact-sheets/detail/zika-virus
https://www.cdc.gov/zika/about/index.html
https://www.cdc.gov/mmwr/volumes/66/wr/mm6612a4.htm
[Accessed: November 2022]

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