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Respiratory Syncytial Virus (RSV)​

General Information

In addition to the paediatric burden of disease, RSV is increasingly being recognized as an important pathogen in older adults, with infection leading to an increase in hospitalisation rates among those aged 65 years and over, and to increased mortality rates among the frail elderly that approach the rates seen with influenza.

RSV is also a nosocomial threat both to young infants and among immunocompromised and vulnerable individuals.

Respiratory Syncytial Virus (RSV) is a globally prevalent cause of lower respiratory tract infection in all age groups. In infants and young children, the first infection may cause severe bronchiolitis that can sometimes be fatal.

There are currently no licensed vaccines for RSV.

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Epidemiology

RSV accounts for hospitalisation of 1 in 5 young children <5 years diagnosed with acute lower respiratory infections and 1 in 6 in adults >65 years.​

RSV is responsible for 24.8 million of acute respiratory infections episodes and 76,600 deaths each year.

Vaccines
Pipeline

10
Vaccines in
the pipeline

Technology Platforms

  • Live-attenuated virus​ (1)
  • Protein nanoparticles (3)
  • Protein subunit​ (3)
  • mRNA (2)
  • Viral vector (1)

DEVELOPMENT PHASES

  • Phase I (3)
  • Phase II (1)
  • Phase III (6)

TRIAL POPULATION

    Paediatric (3)​
    Adults (2)*​
    Older Adults (5)​

     

    * Maternal immunisation

Source: 
https://www.who.int/teams/health-product-policy-and-standards/standards-and-specifications/vaccine-standardization/respiratory-syncytial-virus-disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320297/
[Accessed: November 2022]

 

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