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Invasive E. Coli Disease

General Information

Extraintestinal pathogenic Escherichia coli (ExPEC) causes the vast majority of urinary tract infections (UTIs), is a leading cause of adult sepsis and bacteremia, and is the second most common cause of neonatal meningitis

ExPEC is also a leading cause of community-onset and healthcare-associated invasive disease particularly in adults over 60 years old. 

Increasing multidrug resistance among ExPEC strains constitutes a major obstacle to treatment and is implicated in increasing numbers of hospitalisations and deaths and increasing healthcare costs associated with ExPEC infections.

ExPEC strains have a great impact on public health and economic burden due to the high incidence of ExPEC infections and its antimicrobial resistance.

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Epidemiology

ExPEC is responsible for 70–95% of community-onset UTIs and approximately 50% of nosocomial UTIs, hence accounting for substantial morbidity, mortality, and medical expenses.

Vaccines
Pipeline

1
Vaccines in
the pipeline

Technology Platforms

  • Glycoconjugate vaccine (1)

DEVELOPMENT PHASES

  • Phase III (1)

TRIAL POPULATION

  • Older Adults (1)

Sources: 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676548
https://www.frontiersin.org/articles/10.3389/fmicb.2020.598305/fullhttps://www.frontiersin.org/articles/10.3389/fmicb.2012.00009/full
https://pubmed.ncbi.nlm.nih.gov/35749579/
[Accessed: November 2022]

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