Glioblastoma (GBM) is a fast-growing and aggressive brain tumor that can result in death in six months or less, if untreated.​

Median age of diagnosis is 64 years and it is more common in men as compared to women.

GBMs present unique treatment challenges due to the localisation of tumors in the brain, inherent resistance to conventional therapy, limited capacity of the brain to repair itself, migration of malignant cells into adjacent brain tissue and the variably disrupted tumor blood supply, which inhibits effective drug delivery.​