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Rabies

General Information

Rabies is a viral disease which occurs in more than 150 countries and territories. Dogs are the main source of human rabies deaths, contributing up to 99% of all rabies transmissions to humans.

Globally rabies causes an estimated cost of US$ 8.6 billion per year.

Prevention is possible by vaccination, including post-exposure immunisation to be given as soon after the exposure as possible.​

Symptoms

After an incubation period of 3–8 weeks, non-specific symptoms appear, such as headache, fever and numbness of the skin around the site of the bite. A phase of seizures and eventually coma follows, which almost invariably leads to the patient’s death.

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Epidemiology

Infection causes tens of thousands of deaths every year, mainly in Asia and Africa.

Vaccines
Pipeline

2
Vaccines in
the pipeline

Technology Platforms

  • mRNA (1)
  • Whole-inactivated virus (1)

DEVELOPMENT PHASES

  • Phase I (1)
  • Phase III (1)

TRIAL POPULATION

    Adults (1)​
    Paediatric + Adults + Older Adults (1)​

Sources: 
https://www.who.int/news-room/fact-sheets/detail/rabies
https://www.ecdc.europa.eu/en/rabies
[Accessed: November 2022]

Vaccines Europe Pipeline Review

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