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Rabies

General Information

Rabies is a viral disease which occurs in more than 150 countries and territories. Dogs are the main source of human rabies deaths, contributing up to 99% of all rabies transmissions to humans.

Globally rabies causes an estimated cost of $8.6 billion per year.

Prevention is possible by vaccination, including post-exposure immunisation to be given as soon after the exposure as possible.

Transmission

Dogs are the main source of human rabies deaths, contributing up to 99% of all rabies transmissions to humans, according to the geographic area. Rabies spreads to people and animals via saliva, usually through bites, scratches or direct contact with mucosa.

Symptoms

After an incubation period of 3–8 weeks, non-specific symptoms appear, such as headache, fever and numbness of the skin around the site of the bite. A phase of seizures and eventually coma follows, which almost invariably leads to the patient’s death.
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Epidemiology

Infection causes tens of thousands of deaths every year, mainly in Asia and Africa.

Vaccines
Pipeline

2
Vaccines in
the pipeline

Technology Platforms

  • mRNA (1)
  • Whole-inactivated virus (1)

DEVELOPMENT PHASES

  • Phase I (1)
  • Phase III (1)

TRIAL POPULATION

    Adults (1)​
    Paediatric + Adults + Older Adults (1)​

Source:
WHO. Rabies.2023 [cited 2023 August]. Available from: https://www.who.int/news-room/fact-sheets/detail/rabies.
ECDC. Rabies. [cited 2023 August]. Available from: https://www.ecdc.europa.eu/en/rabies

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