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Malaria

General Information

Malaria is a life-threatening disease caused by Plasmodium parasites that are transmitted to people through the bites of infected female mosquitoes. It is preventable and curable.

The first symptoms – fever, headache and chills – usually appear 10–15 days after the infective mosquito bite and may be mild and difficult to recognise as malaria. Left untreated, malaria can progress to severe illness and death within a period of 24 hours.

The WHO African Region carries a disproportionately high share of the global malaria burden. In 2020, the region was home to 95% of malaria cases and 96% of malaria deaths. Children under 5 accounted for about 80% of all malaria deaths in the Region.

Since October 2021, WHO recommends broad use of the RTS,S/AS01 malaria vaccine among children living in regions with moderate to high malaria transmission. The vaccine has been shown to significantly reduce malaria, and deadly severe malaria among young children.

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Epidemiology

2020

In 2020, there were an estimated 241 million cases of malaria worldwide, with a number of deaths of 627,000.

Vaccines
Pipeline

2
Vaccines in
the pipeline

Technology Platforms

  • Protein nanoparticles (1)
  • Protein subunit​ (1)

DEVELOPMENT PHASES

  • Phase II (1)
  • Phase III (1)

TRIAL POPULATION

    Paediatric (1)​
    Paediatric + Adults (1)​

Source: 
https://www.who.int/news-room/fact-sheets/detail/malaria
[Accessed: November 2022]

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