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Malaria

General Information

Malaria is a life-threatening disease caused by Plasmodium parasites that is preventable and curable.

The WHO African Region carries a disproportionately high share of the global malaria burden. In 2020, the region was home to 95% of malaria cases and 96% of malaria deaths. Children under 5 accounted for about 80% of all malaria deaths in the Region.

Since October 2021, WHO recommends broad use of the RTS,S/AS01 malaria vaccine among children living in regions with moderate to high malaria transmission. The vaccine has been shown to significantly reduce malaria, and deadly severe malaria among young children.

Transmission

Malaria is transmitted through the bites of infected female mosquitoes.

Symptoms

The first symptoms – fever, headache and chills – usually appear 10–15 days after the infective mosquito bite and may be mild and difficult to recognise as malaria. Left untreated, malaria can progress to severe illness and death within a period of 24 hours.
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Epidemiology

2021

In 2021, 247 million cases of malaria worldwide and 619,000 deaths.

Vaccines
Pipeline

2
Vaccines in
the pipeline

Technology Platforms

  • Protein nanoparticles (1)
  • Protein subunit​ (1)

DEVELOPMENT PHASES

  • Phase II (1)
  • Phase III (1)

TRIAL POPULATION

    Paediatric (1)​
    Paediatric + Adults (1)​

Source:
WHO. Malaria. 2023 [cited 2023 August]. Available from: https://www.who.int/news-room/fact-sheets/detail/malaria

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