ExPEC is responsible for 70–95% of community-onset UTIs and approximately 50% of nosocomial UTIs, hence accounting for substantial morbidity, mortality, and medical expenses.
Extraintestinal pathogenic Escherichia coli (ExPEC)
General Information
Extraintestinal pathogenic Escherichia coli (ExPEC) causes the vast majority of urinary tract infections (UTIs), is a leading cause of adult sepsis and bacteremia, and is the second most common cause of neonatal meningitis.
ExPEC is also a leading cause of community-onset and healthcare-associated invasive disease particularly in adults over 60 years old.
Increasing multidrug resistance among ExPEC strains constitutes a major obstacle to treatment and is implicated in increasing numbers of hospitalisations and deaths and increasing healthcare costs associated with ExPEC infections.
ExPEC strains have a great impact on public health and economic burden due to the high incidence of ExPEC infections and its antimicrobial resistance.
Epidemiology
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