ExPEC is responsible for 70–95% of community-onset UTIs and approximately 50% of nosocomial UTIs, hence accounting for substantial morbidity, mortality, and medical expenses.
Extraintestinal pathogenic Escherichia coli (ExPEC) causes the vast majority of urinary tract infections (UTIs), is a leading cause of adult sepsis and bacteremia, and is the second most common cause of neonatal meningitis.
ExPEC is also a leading cause of community-onset and healthcare-associated invasive disease particularly in adults over 60 years old.
Increasing multidrug resistance among ExPEC strains constitutes a major obstacle to treatment and is implicated in increasing numbers of hospitalisations and deaths and increasing healthcare costs associated with ExPEC infections.
ExPEC strains have a great impact on public health and economic burden due to the high incidence of ExPEC infections and its antimicrobial resistance.
ExPEC is responsible for 70–95% of community-onset UTIs and approximately 50% of nosocomial UTIs, hence accounting for substantial morbidity, mortality, and medical expenses.