ExPEC is responsible for 70–95% of community-onset UTIs and approximately 50% of nosocomial UTIs, hence accounting for substantial morbidity, mortality, and medical expenses.
Invasive Escherichia Coli Disease
General Information
Extraintestinal pathogenic Escherichia coli (ExPEC) is a leading cause of community-onset and healthcare-associated invasive disease particularly in adults over 60 years old.
Increasing multidrug resistance among ExPEC strains constitutes a major obstacle to treatment and is implicated in increasing numbers of hospitalisations and deaths and increasing healthcare costs associated with ExPEC infections.
ExPEC strains have a great impact on public health and economic burden due to the high incidence of ExPEC infections and its antimicrobial resistance.
Transmission
Foodborne, waterborne and sexually-transmitted disease.
Symptoms
ExPEC causes the vast majority of urinary tract infections (UTIs), is a leading cause of adult sepsis and bacteremia, and is the second most common cause of neonatal meningitis.
Epidemiology
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